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The in vivo comet assay: use and status in genotoxicity testing

The in vivo comet assay: use and status in genotoxicity testing,10.1093/mutage/gei033,Mutagenesis,Susanne Brendler-Schwaab,Andreas Hartmann,Stefan Pfu

The in vivo comet assay: use and status in genotoxicity testing   (Citations: 49)
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Journal: Mutagenesis , vol. 20, no. 4, pp. 245-254, 2005
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    • ...This assay has the advantages of requiring a small number of cells per sample, being amenable to almost all cell types whether actively dividing or quiescent, and being relatively inexpensive, since only basic equipment is required (Tice et al., 2000; Hartmann et al., 2001, 2003; Brendler-Schwaab et al., 2005)...

    L. S. Castroet al. Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extr...

    • ...The reasons for selecting short-term sampling times in the Comet assay is that DNA lesions detected by this method are short-lived events (they undergo rapid DNA repair) and therefore, have to be captured before they disappear (Brendler-Schwaab et al., 2005)...

    D. J. Brusick. A critical review of the genetic toxicity of steviol and steviol glyco...

    • ... in the comet assay were repaired and this prevented the observation of micronuclei; (ii) the lesions induced in the comet assay were mainly single-strand breaks, which are less effective at producing chromosome fragments than double-strand breaks (29) and (iii) the prevalent DNA lesions leading to effects in the comet assay may have been DNA modifications, such as abasic sites involved predominantly in the induction of gene mutations (30) ...

    Juliana Mara Serpeloniet al. In vivo assessment of DNA damage and protective effects of extracts fr...

    • ...Within the last 10 years or so, single-cell gel electrophoresis, or the comet assay, was established as one of the standard methods for evaluating DNA damage (15,16)...

    Yong Jianget al. Detecting Ultraviolet Damage in Single DNA Molecules by Atomic Force M...

    • ...Faust et al. 2004) ● Aquatic biomonitoring (Mitchelmore and Chipman 1998) ● Genotoxicity testing (Brendler-Schwaab et al. 2005; Moller 2005) ● Carcinogen monitoring (Anderson et al. 1998) ● Genetic ecotoxicology (Cotelle and Ferard 1999) (with the application of the comet assay in plants, worms, molluscs, fish, amphibians and mammalians) ● Various applications (Rojas et al. 1999; Collins 2004)...

    Wolfgang-Ulrich Müller. Comet Assay

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