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Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of Cymbopogan citratus (lemon grass) against colorectal and breast carcinoma cell lines

Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of Cymbopogan citratus (lemon grass) against colorectal and br

Chemical composition, anti-angiogenic and cytotoxicity activities of the essential oils of Cymbopogan citratus (lemon grass) against colorectal and breast carcinoma cell lines  
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The essential oil of Cymbopogan citratus (lemon grass) was isolated by steam distillation method and subjected to cytotoxicity activity using two different cell lines, human colon carcinoma (HCT-116), breast carcinoma cell lines (MCF-7) and anti-angiogenic activity. The cytotoxicity activity study was determined using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2,4-tetrazolium bromide] assay and anti-angiogenic activity using rat aortic ring model. The chemical composition of the essential oil was determined by gas chromatography–mass spectrometry (GC–MS) and GC–flame ionization detection (FID). Forty-one compounds, representing 88.5% of the lemon grass oil was identified and the main components were neral (29.8%) and geranial (44.6%). The free radical scavenging activity of the essential oil showed an IC50 value of 156.1 μg/mL. The results showed that essential oil of lemon grass possessed potential cytotoxic effect on HCT-116 and with the IC50 value of 27.41 ± 4.3 μg/mL comparing to MCF-7 with IC50 value of 41.90 ± 1.2 μg/mL. Significant anti-angiogenic activity of the sample was observed with 99 ± 0.8% of inhibition at 100 μg/mL.
Journal: Journal of Essential Oil Research - J ESSENT OIL RES , vol. ahead-of-p, no. ahead-of-p, pp. 1-7, 2012
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